支部例会紹介文献コーナー

2023.8.20　中年期の歯周治療

【歯周病発症時期】

1. 重度歯周炎の有病率と罹患率について
   Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014 Nov;93(11):1045-53. doi: 10.1177/0022034514552491. Epub 2014 Sep 26. PMID: 25261053; PMCID: PMC4293771.

【根分岐部病変のマネージメント】

1. 分岐部のHampの分類
   Hamp SE, Nyman S, Lindhe J. Periodontal treatment of multirooted teeth. Results after 5 years. J Clin Periodontol. 1975 Aug;2(3):126-35. doi: 10.1111/j.1600-051x.1975.tb01734.x. PMID: 1058213.
2. 2度の分岐部病変のサブクラス分類（A,B,C）での10年生存率の差
   Tonetti MS, Christiansen AL, Cortellini P. Vertical subclassification predicts survival of molars with class II furcation involvement during supportive periodontal care. J Clin Periodontol. 2017 Nov;44(11):1140-1144. doi: 10.1111/jcpe.12789. Epub 2017 Sep 22. PMID: 28771794.
3. 分岐部への再生療法の関連因子
   Bowers GM, Schallhorn RG, McClain PK, Morrison GM, Morgan R, Reynolds MA. Factors influencing the outcome of regenerative therapy in mandibular Class II furcations: Part I. J Periodontol. 2003 Sep;74(9):1255-68. doi: 10.1902/jop.2003.74.9.1255. PMID: 14584858.
4. エナメルプロジェクションの形態
   江澤 著, １からわかるクリニカルペリオドンとロジー, 医歯薬, 2001
5. バイファーケーションリッジの形態
   EVERETT FG, JUMP EB, HOLDER TD, WILLIAMS GC. The intermediate bifurcational ridge: a study of the morphology of the bifurcation of the lower first molar. J Dent Res. 1958 Feb;37(1):162-9. doi: 10.1177/00220345580370011001. PMID: 13513891.
6. 日本人の上顎第一小臼歯の歯根の数
   岡本　治, 写真で見る歯根と根管の形態, 医歯薬, 1983
7. 上顎第一小臼歯の陥凹の頻度
   Booker BW 3rd, Loughlin DM. A morphologic study of the mesial root surface of the adolescent maxillary first bicuspid. J Periodontol. 1985 Nov;56(11):666-70. doi: 10.1902/jop.1985.56.11.666. PMID: 3863916.
8. 上顎大臼歯の歯根の陥凹の形態（日本人）
   Ezawa, T, A morphological study of the first molar root surface, Int. congress series/Excerpta medica 790 435-438, 1988
9. 上顎大臼歯の歯根の陥凹の形態（アメリカ人）
   Bower RC. Furcation morphology relative to periodontal treatment. Furcation entrance architecture. J Periodontol. 1979 Jan;50(1):23-7. doi: 10.1902/jop.1979.50.1.23. PMID: 283222.
10. 多根歯の長期SPTにおける分岐部の重症度ごとのリスク比
    Salvi GE, Mischler DC, Schmidlin K, Matuliene G, Pjetursson BE, Brägger U, Lang NP. Risk factors associated with the longevity of multi-rooted teeth. Long-term outcomes after active and supportive periodontal therapy. J Clin Periodontol. 2014 Jul;41(7):701-7. doi: 10.1111/jcpe.12266. Epub 2014 May 26. PMID: 24766602.
11. SPT中（平均18年）の根分岐部病変の程度による、長期予後
    Graetz C, Schützhold S, Plaumann A, Kahl M, Springer C, Sälzer S, Holtfreter B, Kocher T, Dörfer CE, Schwendicke F. Prognostic factors for the loss of molars--an 18-years retrospective cohort study. J Clin Periodontol. 2015 Oct;42(10):943-50. doi: 10.1111/jcpe.12460. Epub 2015 Oct 26. PMID: 26399690.
12. 2020 EFP 診療ガイドライン　根分岐部病変への再生療法の適応について
    Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, Sculean A, Tonetti MS; EFP Workshop Participants and Methodological Consultants. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2020 Jul;47 Suppl 22(Suppl 22):4-60. doi: 10.1111/jcpe.13290. Erratum in: J Clin Periodontol. 2021 Jan;48(1):163. PMID: 32383274; PMCID: PMC7891343.
13. 2020 EFP 診療ガイドライン　再生療法　引用文献
    Jepsen S, Gennai S, Hirschfeld J, Kalemaj Z, Buti J, Graziani F. Regenerative surgical treatment of furcation defects: A systematic review and Bayesian network meta-analysis of randomized clinical trials. J Clin Periodontol. 2020 Jul;47 Suppl 22:352-374. doi: 10.1111/jcpe.13238. PMID: 31860125.
14. 2020 EFP 診療ガイドライン　切除療法　引用文献
    Dommisch H, Walter C, Dannewitz B, Eickholz P. Resective surgery for the treatment of furcation involvement: A systematic review. J Clin Periodontol. 2020 Jul;47 Suppl 22:375-391. doi: 10.1111/jcpe.13241. PMID: 31912534.Huynh-Ba, J Clin Periodontol, 2009
15. 根分岐部病変を伴う臼歯の各治療別の生存率
    Huynh-Ba G, Kuonen P, Hofer D, Schmid J, Lang NP, Salvi GE. The effect of periodontal therapy on the survival rate and incidence of complications of multirooted teeth with furcation involvement after an observation period of at least 5 years: a systematic review. J Clin Periodontol. 2009 Feb;36(2):164-76. doi: 10.1111/j.1600-051X.2008.01358.x. PMID: 19207893.
16. 歯周補綴治療において、歯根切除を行った場合、歯根破折のリスクが優位に高くなる
    Di Febo G, Bedendo A, Romano F, Cairo F, Carnevale G. Fixed prosthodontic treatment outcomes in the long-term management of patients with periodontal disease: a 20-year follow-up report. Int J Prosthodont. 2015 May-Jun;28(3):246-51. doi: 10.11607/ijp.3995. Erratum in: Int J Prosthodont. 2015 Jul-Aug;28(4):424. Bebendo, Attilio [corrected to Bedendo, Attilio]. PMID: 25965638.
17. 歯を保存すべきか？抜歯すべきか？ライフステージに応じた臨床上の意思決定と治療戦略
    Lundgren D, Rylander H, Laurell L. To save or to extract, that is the question. Natural teeth or dental implants in periodontitis-susceptible patients: clinical decision-making and treatment strategies exemplified with patient case presentations. Periodontol 2000. 2008;47:27-50. doi: 10.1111/j.1600-0757.2007.00239.x. PMID: 18412572.

【メインテナンス】

1. Lang NP, Tonetti MS. Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT). Oral Health Prev Dent. 2003;1(1):7-16. PMID: 15643744.
2. Trombelli L, Simonelli A, Franceschetti G, Maietti E, Farina R. What periodontal recall interval is supported by evidence? Periodontol 2000. 2020 Oct;84(1):124-133. doi: 10.1111/prd.12340. PMID: 32844410.
3. Becker W, Berg L, Becker BE. Untreated periodontal disease: a longitudinal study. J Periodontol. 1979 May;50(5):234-44. doi: 10.1902/jop.1979.50.5.234. PMID: 287779.
4. Becker W, Becker BE, Berg LE. Periodontal treatment without maintenance. A retrospective study in 44 patients. J Periodontol. 1984 Sep;55(9):505-9. doi: 10.1902/jop.1984.55.9.505. PMID: 6592322.
5. Becker W, Berg L, Becker BE. The long term evaluation of periodontal treatment and maintenance in 95 patients. Int J Periodontics Restorative Dent. 1984;4(2):54-71. PMID: 6589217.
6. Axelsson P, Lindhe J. The significance of maintenance care in the treatment of periodontal disease. J Clin Periodontol. 1981 Aug;8(4):281-94. doi: 10.1111/j.1600-051x.1981.tb02039.x. PMID: 6947992.
7. Graetz C, Sälzer S, Plaumann A, Schlattmann P, Kahl M, Springer C, Dörfer C, Schwendicke F. Tooth loss in generalized aggressive periodontitis: Prognostic factors after 17 years of supportive periodontal treatment. J Clin Periodontol. 2017 Jun;44(6):612-619. doi: 10.1111/jcpe.12725. Epub 2017 Apr 27. PMID: 28346706.
8. Hirschfeld L, Wasserman B. A long-term survey of tooth loss in 600 treated periodontal patients. J Periodontol. 1978 May;49(5):225-37. doi: 10.1902/jop.1978.49.5.225. PMID: 277674.
9. Agudio G, Buti J, Bonaccini D, Pini Prato G, Cortellini P. Longevity of teeth in patients susceptible to periodontitis: Clinical outcomes and risk factors associated with tooth loss after active therapy and 30 years of supportive periodontal care. J Clin Periodontol. 2023 Apr;50(4):520-532. doi: 10.1111/jcpe.13770. Epub 2023 Jan 17. PMID: 36631984.
10. Slot DE, Valkenburg C, Van der Weijden GAF. Mechanical plaque removal of periodontal maintenance patients: A systematic review and network meta-analysis. J Clin Periodontol. 2020 Jul;47 Suppl 22:107-124. doi: 10.1111/jcpe.13275. PMID: 32716118.
11. Worthington HV, MacDonald L, Poklepovic Pericic T, Sambunjak D, Johnson TM, Imai P, Clarkson JE. Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries. Cochrane Database Syst Rev. 2019 Apr 10;4(4):CD012018. doi: 10.1002/14651858.CD012018.pub2. PMID: 30968949; PMCID: PMC6953268.
12. Manresa C, Sanz-Miralles EC, Twigg J, Bravo M. Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis. Cochrane Database Syst Rev. 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2. PMID: 29291254; PMCID: PMC6491071.
13. Abdulbaqi HR, Shaikh MS, Abdulkareem AA, Zafar MS, Gul SS, Sha AM. Efficacy of erythritol powder air-polishing in active and supportive periodontal therapy: A systematic review and meta-analysis. Int J Dent Hyg. 2022 Feb;20(1):62-74. doi: 10.1111/idh.12539. Epub 2021 Aug 2. PMID: 34318577.

2023.4.23　若年層の歯周治療

【歯周治療のガイドライン】

1. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999 Dec;4(1):1-6. doi: 10.1902/annals.1999.4.1.1. PMID: 10863370.
2. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018 Jun;89 Suppl 1:S159-S172. doi: 10.1002/JPER.18-0006. Erratum in: J Periodontol. 2018 Dec;89(12):1475. PMID: 29926952.
3. Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S173-S182. doi: 10.1002/JPER.17-0721. PMID: 29926951.
4. Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018 Jun;45 Suppl 20:S162-S170. doi: 10.1111/jcpe.12946. PMID: 29926490.
5. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Clin Periodontol. 2018 Jun;45 Suppl 20:S149-S161. doi: 10.1111/jcpe.12945. Erratum in: J Clin Periodontol. 2019 Jul;46(7):787. PMID: 29926495.
6. Tonetti MS, Sanz M. Implementation of the new classification of periodontal diseases: Decision-making algorithms for clinical practice and education. J Clin Periodontol. 2019 Apr;46(4):398-405. doi: 10.1111/jcpe.13104. PMID: 30883878.
7. Highfield J. Diagnosis and classification of periodontal disease. Aust Dent J. 2009 Sep;54 Suppl 1:S11-26. doi: 10.1111/j.1834-7819.2009.01140.x. PMID: 19737262.
8. Herrera D, Sanz M, Kebschull M, Jepsen S, Sculean A, Berglundh T, Papapanou PN, Chapple I, Tonetti MS; EFP Workshop Participants and Methodological Consultant. Treatment of stage IV periodontitis: The EFP S3 level clinical practice guideline. J Clin Periodontol. 2022 Jun;49 Suppl 24:4-71. doi: 10.1111/jcpe.13639. PMID: 35688447.
9. Tabaa M, Adatowovor R, Shabila A, Morford L, Dawson D, Harrison P, Aukhil I, Huang H, Stromberg A, Goncalves J, Shaddox LM. Pattern of grade C molar-incisor pattern periodontitis in families. J Periodontol. 2023 Jul;94(7):811-822. doi: 10.1002/JPER.22-0317. Epub 2023 Jun 1. PMID: 36370032.
10. Chen MX, Zhong YJ, Dong QQ, Wong HM, Wen YF. Global, regional, and national burden of severe periodontitis, 1990-2019: An analysis of the Global Burden of Disease Study 2019. J Clin Periodontol. 2021 Sep;48(9):1165-1188. doi: 10.1111/jcpe.13506. Epub 2021 Jul 7. PMID: 34101223.
11. Bouziane A, Hamdoun R, Abouqal R, Ennibi O. Global prevalence of aggressive periodontitis: A systematic review and meta-analysis. J Clin Periodontol. 2020 Apr;47(4):406-428. doi: 10.1111/jcpe.13266. Epub 2020 Feb 20. PMID: 32011029.
12. Uchiyama J, Kawanami M, Konno J, Sugano T, Tsukuda N, Tsukamoto K, Kobayashi I, Hsu HF, Shojiguchi K, Kohsen Y, et al. [Prevalence of juvenile periodontitis in 15-18-year-old students in Japan. I. Findings of the first and second screenings]. Nihon Shishubyo Gakkai Kaishi. 1983 Dec;25(4):888-97. Japanese. PMID: 6586898.
13. Uchiyama J, Kawanami M, Konno J, Sugano T, Tsukuda N, Tsukamoto K, Kiba A, Shiraishi Y, Ishikawa J. [Prevalence of juvenile periodontitis in 15-18-year-old students in Japan. II. Findings of the final detailed examination]. Nihon Shishubyo Gakkai Kaishi. 1983 Dec;25(4):898-907. Japanese. PMID: 6586899.
14. Kowashi Y. Prevalence of juvenile periodontitis among students at Nagasaki University. Adv Dent Res. 1988 Nov;2(2):395-6. doi: 10.1177/08959374880020023501. PMID: 3271036.
15. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997 Jun;14:9-11. doi: 10.1111/j.1600-0757.1997.tb00189.x. PMID: 9567963.
16. Roberts FA, Darveau RP. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 2000. 2015 Oct;69(1):18-27. doi: 10.1111/prd.12087. PMID: 26252399; PMCID: PMC4530467.
17. Tsukasaki M, Takayanagi H. Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol. 2019 Oct;19(10):626-642. doi: 10.1038/s41577-019-0178-8. Epub 2019 Jun 11. PMID: 31186549.
18. Branco-de-Almeida LS, Velsko IM, de Oliveira ICV, de Oliveira RCG, Shaddox LM. Impact of Treatment on Host Responses in Young Individuals with Periodontitis. J Dent Res. 2023 May;102(5):473-488. doi: 10.1177/00220345221148161. Epub 2023 Feb 18. PMID: 36803061; PMCID: PMC10150440.
19. Sudo T, Okada Y, Ozaki K, Urayama K, Kanai M, Kobayashi H, Gokyu M, Izumi Y, Tanaka T. Association of NOD2 Mutations with Aggressive Periodontitis. J Dent Res. 2017 Sep;96(10):1100-1105. doi: 10.1177/0022034517715432. Epub 2017 Jul 6. PMID: 28682159.
20. Kitagaki J, Miyauchi S, Asano Y, Imai A, Kawai S, Michikami I, Yamashita M, Yamada S, Kitamura M, Murakami S. A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population. PLoS One. 2016 Aug 10;11(8):e0160765. doi: 10.1371/journal.pone.0160765. PMID: 27509131; PMCID: PMC4979892.

【GAgP,GradeCの概論】

1. Highfield J. Diagnosis and classification of periodontal disease. Aust Dent J. 2009 Sep;54 Suppl 1:S11-26. doi: 10.1111/j.1834-7819.2009.01140.x. PMID: 19737262.
2. 歯周炎GradeCとインプラント
   Mengel R, Stelzel M, Hasse C, Flores-de-Jacoby L. Osseointegrated implants in patients treated for generalized severe adult periodontitis. An interim report. J Periodontol. 1996 Aug;67(8):782-7. doi: 10.1902/jop.1996.67.8.782. PMID: 8866317.
3. 侵襲性Pのインプラント５年成功率８８.８％
   Mengel R, Schröder T, Flores-de-Jacoby L. Osseointegrated implants in patients treated for generalized chronic periodontitis and generalized aggressive periodontitis: 3- and 5-year results of a prospective long-term study. J Periodontol. 2001 Aug;72(8):977-89. doi: 10.1902/jop.2001.72.8.977. PMID: 11525449.
4. 歯周炎GradeCとインプラント
   Mengel R, Flores-de-Jacoby L. Implants in patients treated for generalized aggressive and chronic periodontitis: a 3-year prospective longitudinal study. J Periodontol. 2005 Apr;76(4):534-43. doi: 10.1902/jop.2005.76.4.534. PMID: 15857093.
5. 侵襲性Pのインプラント成功率１０年で８３％
   Mengel R, Behle M, Flores-de-Jacoby L. Osseointegrated implants in subjects treated for generalized aggressive periodontitis: 10-year results of a prospective, long-term cohort study. J Periodontol. 2007 Dec;78(12):2229-37. doi: 10.1902/jop.2007.070201. PMID: 18052693.
6. 侵襲性Pインプラント周囲炎１４倍のリスク
   Swierkot K, Lottholz P, Flores-de-Jacoby L, Mengel R. Mucositis, peri-implantitis, implant success, and survival of implants in patients with treated generalized aggressive periodontitis: 3- to 16-year results of a prospective long-term cohort study. J Periodontol. 2012 Oct;83(10):1213-25. doi: 10.1902/jop.2012.110603. Epub 2012 Jan 20. PMID: 22264211.
7. 全抜歯してインプラントしても歯周病原細菌いる
   Danser MM, van Winkelhoff AJ, van der Velden U. Periodontal bacteria colonizing oral mucous membranes in edentulous patients wearing dental implants. J Periodontol. 1997 Mar;68(3):209-16. doi: 10.1902/jop.1997.68.3.209. PMID: 9100195.
8. Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Periodontitis, implant loss and peri-implantitis. A meta-analysis. Clin Oral Implants Res. 2015 Apr;26(4):e8-e16. doi: 10.1111/clr.12319. Epub 2013 Dec 31. PMID: 24382358.
9. 侵襲性Pのall on 4
   Li S, Di P, Zhang Y, Lin Y. Immediate implant and rehabilitation based on All-on-4 concept in patients with generalized aggressive periodontitis: A medium-term prospective study. Clin Implant Dent Relat Res. 2017 Jun;19(3):559-571. doi: 10.1111/cid.12483. Epub 2017 Apr 3. PMID: 28371086.
10. 侵襲性Pはインプラント喪失リスク４倍
    Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Periodontitis, implant loss and peri-implantitis. A meta-analysis. Clin Oral Implants Res. 2015 Apr;26(4):e8-e16. doi: 10.1111/clr.12319. Epub 2013 Dec 31. PMID: 24382358.
11. 全抜歯して半年後にも舌などには歯周病原菌がいた
    Van Assche N, Van Essche M, Pauwels M, Teughels W, Quirynen M. Do periodontopathogens disappear after full-mouth tooth extraction? J Clin Periodontol. 2009 Dec;36(12):1043-7. doi: 10.1111/j.1600-051X.2009.01477.x. PMID: 19930094.
12. 侵襲性Pは３年でもMBL大きい
    Theodoridis C, Grigoriadis A, Menexes G, Vouros I. Outcomes of implant therapy in patients with a history of aggressive periodontitis. A systematic review and meta-analysis. Clin Oral Investig. 2017 Mar;21(2):485-503. doi: 10.1007/s00784-016-2026-6. Epub 2016 Dec 24. Erratum in: Clin Oral Investig. 2017 Apr;21(3):965. PMID: 28013438.
13. 侵襲性Pの矯正の場合どの歯でも炎症のコントロールでポケットは減少する
    Carvalho CV, Saraiva L, Bauer FPF, Kimura RY, Souto MLS, Bernardo CC, Pannuti CM, Romito GA, Pustiglioni FE. Orthodontic treatment in patients with aggressive periodontitis. Am J Orthod Dentofacial Orthop. 2018 Apr;153(4):550-557. doi: 10.1016/j.ajodo.2017.08.018. PMID: 29602347.
14. 侵襲性Pの矯正レビュー
    Gyawali R, Bhattarai B. Orthodontic Management in Aggressive Periodontitis. Int Sch Res Notices. 2017 Feb 16;2017:8098154. doi: 10.1155/2017/8098154. PMID: 28299350; PMCID: PMC5337368.
15. 侵襲性P矯正ケースレポート
    Syrowik, L.M., Janic, A.L. and Jacobs, L.C. (2014), Management of Generalized Aggressive Periodontitis Using Periodontal and Orthodontic Treatments. Clinical Advances in Periodontics, 4: 73-79. https://doi.org/10.1902/cap.2012.120056
16. 侵襲性P矯正９年ケースレポート
    Closs LQ, Gomes SC, Oppermann RV, Bertoglio V. Combined periodontal and orthodontic treatment in a patient with aggressive periodontitis: a 9-year follow-up report. World J Orthod. 2010 Fall;11(3):291-7. PMID: 20877741.
17. 侵襲性P矯正ケースレポート
    Alessandro Lanza, Fabrizio Di Francesco, Gennaro De Marco, Fabio Scognamiglio, Valeria Aruta, Angelo Itro, "Multidisciplinary Approach in the Management of a Complex Case: Implant-Prosthetic Rehabilitation of a Periodontal Smoking Patient with Partial Edentulism, Malocclusion, and Aesthetic Diseases", Case Reports in Dentistry, vol. 2017, Article ID 6348570, 6 pages, 2017. https://doi.org/10.1155/2017/6348570
18. 侵襲性P矯正ケースレポート
    Motta ATSD. Orthodontic treatment in the presence of aggressive periodontitis. Dental Press J Orthod. 2021 Dec 17;26(6):e21bbo6. doi: 10.1590/2177-6709.26.6.e21bbo6. PMID: 34932773; PMCID: PMC8690590.
19. Perioの矯正SysRev
    Martin C, Celis B, Ambrosio N, Bollain J, Antonoglou GN, Figuero E. Effect of orthodontic therapy in periodontitis and non-periodontitis patients: a systematic review with meta-analysis. J Clin Periodontol. 2022 Jun;49 Suppl 24:72-101. doi: 10.1111/jcpe.13487. Epub 2021 Nov 22. PMID: 33998045.
20. 重度歯周炎の矯正SysRev
    Erbe C, Heger S, Kasaj A, Berres M, Wehrbein H. Orthodontic treatment in periodontally compromised patients: a systematic review. Clin Oral Investig. 2023 Jan;27(1):79-89. doi: 10.1007/s00784-022-04822-1. Epub 2022 Dec 11. PMID: 36502508; PMCID: PMC9877066.

【抗菌療法】

1. ヨーロッパ歯周病連盟のステージⅣ歯周炎治療のガイドライン
   Herrera D, Sanz M, Kebschull M, Jepsen S, Sculean A, Berglundh T, Papapanou PN, Chapple I, Tonetti MS; EFP Workshop Participants and Methodological Consultant. Treatment of stage IV periodontitis: The EFP S3 level clinical practice guideline. J Clin Periodontol. 2022 Jun;49 Suppl 24:4-71. doi: 10.1111/jcpe.13639. PMID: 35688447.
2. 歯周治療における抗菌薬の付加的効果　システマティックレビュー
   Teughels W, Feres M, Oud V, Martín C, Matesanz P, Herrera D. Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis. J Clin Periodontol. 2020 Jul;47 Suppl 22:257-281. doi: 10.1111/jcpe.13264. PMID: 31994207.
3. ステージⅡ-ⅢグレードC（侵襲性歯周炎）におけるアモキシシリンとメトロニダゾールの効果
   Karrabi M, Baghani Z. Amoxicillin/Metronidazole Dose Impact as an Adjunctive Therapy for Stage II - III Grade C Periodontitis (Aggressive Periodontitis) at 3- And 6-Month Follow-Ups: a Systematic Review and Meta-Analysis. J Oral Maxillofac Res. 2022 Mar 31;13(1):e2. doi: 10.5037/jomr.2022.13102. PMID: 35574209; PMCID: PMC9069637.
4. 若年性歯周炎患者の宿主反応への歯周治療の影響
   Branco-de-Almeida LS, Velsko IM, de Oliveira ICV, de Oliveira RCG, Shaddox LM. Impact of Treatment on Host Responses in Young Individuals with Periodontitis. J Dent Res. 2023 May;102(5):473-488. doi: 10.1177/00220345221148161. Epub 2023 Feb 18. PMID: 36803061; PMCID: PMC10150440.
5. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果①
   Wahlstrom E, Zamora JU, Teichman S. Improvement in cyclosporine-associated gingival hyperplasia with azithromycin therapy. N Engl J Med. 1995 Mar 16;332(11):753-4. doi: 10.1056/NEJM199503163321116. PMID: 7854392.
6. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果②
   Boran M, Güneş Z, Doruk F, Gönenç F, Cetin S. Improvement in cyclosporine A associated gingival hyperplasia with azithromycin therapy. Transplant Proc. 1996 Aug;28(4):2316. PMID: 8769234.
7. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果③
   Puig JM, Lloveras J, Bosch JM, Munné A, Mir M, Barbosa F, Masramon J. Treatment of gingival hyperplasia secondary to cyclosporine by the new macrolide azithromycin. Transplant Proc. 1997 Aug;29(5):2379-80. doi: 10.1016/s0041-1345(97)00411-9. PMID: 9270772.
8. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果④
   Nash MM, Zaltzman JS. Efficacy of azithromycin in the treatment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. Transplantation. 1998 Jun 27;65(12):1611-5. doi: 10.1097/00007890-199806270-00012. PMID: 9665078.
9. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果⑤
   Nowicki M, Kokot F, Wiecek A. Partial regression of advanced cyclosporin-induced gingival hyperplasia after treatment with azithromycin. A case report. Ann Transplant. 1998;3(3):25-7. PMID: 10234432.
10. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果⑥
    Wirnsberger GH, Pfragner R, Mauric A, Zach R, Bogiatzis A, Holzer H. Effect of antibiotic treatment with azithromycin on cyclosporine A-induced gingival hyperplasia among renal transplant recipients. Transplant Proc. 1998 Aug;30(5):2117-9. doi: 10.1016/s0041-1345(98)00558-2. PMID: 9723411.
11. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果⑦
    Citterio F, Di Pinto A, Borzi MT, Scatà MC, Foco M, Pozzetto U, Castagneto M. Azithromycin treatment of gingival hyperplasia in kidney transplant recipients is effective and safe. Transplant Proc. 2001 May;33(3):2134-5. doi: 10.1016/s0041-1345(01)01973-x. PMID: 11377476.
12. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果⑧
    Tokgöz B, Sari HI, Yildiz O, Aslan S, Sipahioğlu M, Okten T, Oymak O, Utaş C. Effects of azithromycin on cyclosporine-induced gingival hyperplasia in renal transplant patients. Transplant Proc. 2004 Nov;36(9):2699-702. doi: 10.1016/j.transproceed.2004.09.059. PMID: 15621128.
13. シクロスポリンによる薬物性歯肉増殖へのアジスロマイシンの効果⑨
    Kumar SS, Mohammad H, Kar K. Management of Cyclosporine-Influenced Gingival Enlargement With Azithromycin. Clin Adv Periodontics. 2020 Sep;10(3):140-144. doi: 10.1002/cap.10097. Epub 2020 May 4. PMID: 32074404.
14. 慢性歯周炎の非外科治療におけるアジスロマイシンの付加的効果　RCTのメタ分析
    Zhang Z, Zheng Y, Bian X. Clinical effect of azithromycin as an adjunct to non-surgical treatment of chronic periodontitis: a meta-analysis of randomized controlled clinical trials. J Periodontal Res. 2016 Jun;51(3):275-83. doi: 10.1111/jre.12319. Epub 2015 Sep 12. PMID: 26362529.
15. 炎症がある歯周組織におけるアジスロマイシン投与後の薬物濃度
    Gomi K, Yashima A, Iino F, Kanazashi M, Nagano T, Shibukawa N, Ohshima T, Maeda N, Arai T. Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. J Periodontol. 2007 May;78(5):918-23. doi: 10.1902/jop.2007.060246. PMID: 17470027.
16. アジスロマイシンを併用したフルマウスSRPと部分的SRPの比較
    Yashima A, Gomi K, Maeda N, Arai T. One-stage full-mouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered azithromycin. J Periodontol. 2009 Sep;80(9):1406-13. doi: 10.1902/jop.2009.090067. PMID: 19722790.

【歯周組織再生療法】

1. 侵襲性歯周炎における歯周組織再生療法の効果　システマティックレビュー
   Díaz-Faes L, Fernández-Somoano A, Magán-Fernández A, Mesa F. Efficacy of regenerative therapy in aggressive periodontitis: a systematic review and meta-analysis of randomised controlled clinical trials. Clin Oral Investig. 2020 Apr;24(4):1369-1378. doi: 10.1007/s00784-020-03237-0. Epub 2020 Feb 14. PMID: 32060656.
2. 侵襲性歯周炎の骨縁下欠損におけるエムドゲインの効果　マルチセンタースタディ
   Fileto Mazzonetto AL, Casarin RCV, Santamaria MP, Andere NMRB, Araújo CF, Videira Clima da Silva R, Purisaca JEV, Sallum EA, Sallum AW. Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial. J Periodontol. 2021 Jul;92(7):995-1006. doi: 10.1002/JPER.20-0493. Epub 2020 Nov 9. PMID: 33107596.
3. エムドゲインを用いた歯周組織再生療法における年齢の影響
   Mikami R, Mizutani K, Shioyama H, Matsuura T, Aoyama N, Suda T, Kusunoki Y, Takeda K, Izumi Y, Aida J, Aoki A, Iwata T. Influence of aging on periodontal regenerative therapy using enamel matrix derivative: A 3-year prospective cohort study. J Clin Periodontol. 2022 Feb;49(2):123-133. doi: 10.1111/jcpe.13552. Epub 2021 Oct 25. PMID: 34545600.

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